Lipid profile in females of reproductive age group using injectable contraceptives [progestogen-only]

To determine and compare the values of lipid profile in married fertile females of reproductive age group using injectable contraceptives. Comparative cross sectional study. This study was carried out in the Department of Biochemistry, Postgraduate Medical Institute, Lahore and Lahore General Hospital, Lahore from July 2010 to Dec 2010. A total of 250 married fertile women in their reproductive age were selected. They were divided in two groups: Group 1 [controls] and Group 2 [injectable contraceptive users]. Levels of s erum total cholesterol, serum triglycerides, high density lipoprotein-cholesterol were measured using standard kits. Low density lipoprotein-cholesterol was calculated with Fried Wald equation. Results were analyzed by using student's t test. Informed consent was taken from each patient and control subject for this study. Injectable contraceptives cause significant decrease in HDL-C and significant increase in serum triglycerides and LDL-C. It is suggested that Lipid profile should be estimated before starting every course [the course may be 3-6months] of injectable contraceptives to the subjects

Association of BMI with elevated values of CK-MB and cTnT in acute myocardial infarction

To determine the association of BMI with serum levels of cTnT and CK-MB isoenzyme in patients presented to hospital emergency with suspected myocardial infarction and in healthy individuals. Comparative cross sectional study. This study was conducted at Post graduate medical institute, Lahore in collaboration with Punjab Institute of Cardiology Lahore from July 2010 to Dec 2010. Serum concentration of CK-MB and Cardiac Troponin T were estimated in 80 patients of AMI [40-60 years of age both sexes] by Immunological UV assay and electrochemiluminescence immunoassay [ECLIA] respectively. 40 healthy controls were matched for age and sex. Low BMI was observed in patients with both sexes. The values of both CK-MB and cTnT were markedly raised in patients with acute myocardial infarction. In the present study higher prevalence of risk factors and MI were seen in patients even with BMI < 23 kg/m 2.Therefore recognition and adoption of BMI cutoffs represent a major step forward in redefining the risk stratification among Pakistanis